Safety and Efficacy

Bacterial burden can seriously affect chronic wounds by prolonging the infl ammatory stage as well as decreasing wound strength via collagenase production in bacteria, neutrophils and macrophages. Vetericyn® VF Plus is a superoxidized hypochlorous autolytic debridement solution for cleansing, irrigating and moisturizing wounds while staying non-toxic, non-irritating and non-sensitizing to the animal. In vitro testing of the preservative in Vetericyn VF Plus shows microbial inhibition activity for a broad range of microorganisms including staphylococcal species.

Comparative Cytotoxic Analysis3

Wound IrrigantResults
Saline (0.9%, NaCl, pH 5.0)Pass
Hypochlorous Solution (0.015%)Pass
Sodium Hypochlorite (Dakin’s) (0.25%)Fail
Sodium Hypochlorite (Dakin’s) (0.5%)Fail
Chlorhexidine gluconate (4%)Fail
Hydrogen peroxide (3%)Fail
Povidone Iodine (7.5%)Fail

Saline, Sterile or Tap Water

While recent studies have found no evidence that saline, sterile or tap water are detrimental to wound healing, there is no evidence of their ability to manage dirty wound debris and fluid during the debridement routine to minimize the re-contamination of chronic wounds.1

The use of saline, sterile or tap water is inappropriate for wound bed preparation in the context of bioburden and biofilm.1

Iodine

Although iodine is a broad spectrum antiseptic, some formulations have been shown, in-vitro, to impair the functioning of the cells involved in normal wound healing.2

1Sampson CM, Sampson MN. Hypochlorous acid: a safe and effi cacious new wound therapy. Poster presented at: World Union of Wound Healing Societies; 2008; Toronto, Ontario, Canada.
2Wolcott R, Fletcher J. The role of wound cleansing in the management of wounds. Wounds International. 2014; 1(1): 25-31.
3Bowler PG, Duerden DI, Armstrong DG. Wound microbiology and associated approaches to wound management. Clinical Microbiology Reviews. 2001; 14(2): 244-269.